![]() ![]() Detailed measurement of HS-CRP and BMD and other covariate obtaining processes can be found at the website: Statistical analysesĪll estimates were derived based on the sample weights of the NHANES in accordance with the NCHS edited analysis guidelines, as the objective of NHANES is to generate data that is representative of the non-institutionalized civilian population of the USA. Moreover, age, gender, race, income-poverty ratio, body mass index (BMI), education level, alkaline phosphatase, cholesterol, calcium, phosphorus, globulin, and total protein were defined as the following covariates. The whole body scans including arms and legs, the trunk, and the head by using a Hologic Discovery A densitometer (Hologic, Inc., Bedford, Massachusetts), and the results of total BMD were obtained using Apex version 3.2 software. The HS-CRP levels were measured using a two-reagent, immunoturbidimetric system. HS-CRP (independent variable) and BMD (dependent variable) were the main variables of this study. All methods were in accordance with the guidelines and regulations of the NCHS Institutional Review Board. The survey program was approved by the NCHS Institutional Review Board, and all participants had provided informed consent on their own or legally authorized representatives 11. The flow chart of sample selection was shown in Fig. Finally, 1747 participants were included in the analysis. Considering that HS-CRP ≥ 10 mg/L was an abnormal stress state 10, 75 subjects were excluded. 509 participants were excluded for missing all blood biochemical data. 649 participants were excluded for HS-CRP missing, and 502 participants were excluded for BMD missing. The inclusion of participants was limited to age 10–20 years (n = 3482). The detail information about the NHANES methodology could be found at the website: For this study, we used data from the 2015 to 2018 survey cycles, when HS-CRP was available. These cross-sectional investigations were carried out by the National Centre for Health Statistics (NCHS). The NHANES is a complex and multi-stage probability sample of the civilian noninstitutionalized population in the United States. Herein, based on the 2015–2018 National Health and Nutrition Examination Surveys (NHANES), we conducted a cross-sectional study with a large sample to investigate the association of HS-CRP with BMD in adolescents aged 10–20 years.Īll analyzed data in this study was extracted from the NHANES. However, there is no evidence linking HS-CRP and BMD in adolescents till now. Thus HS-CRP as a more precise measure than traditional CRP is likely to be a potential indicator of BMD. ![]() Moreover, epidemiologic studies have proved that serum CRP levels are negatively associated with BMD 7, 8, 9. Previous animal studies have shown that inflammatory markers such as CRP are significantly associated with increased bone resorption and decreased bone formation 5, 6. Therefore, some less studied or new biomarkers have been given more attention for their relevance to bone health, such as C-reactive protein (CRP). The clinical assessment of risk factors related to osteoporosis is helpful for the early diagnosis, prevention and management of osteoporosis. In a sense, osteoporosis has also been considered to be an adolescent disease. The acquisition of BMD during this period is essential for bone accumulation and bone formation, in order to obtain a greater peak bone mass, thereby preventing osteoporosis in older age 2, 3, 4. Our results demonstrated that higher HS-CRP was negatively correlated with total BMD in 10–20 years old adolescents.ĭuring adolescence, especially before the age of 20 years, bone accumulation and growth are rapid 1. The negative association was also observed in the subgroup analyses stratified by gender and age. In the multi-regression model that after the potential confounders had been adjusted, HS-CRP was negatively associated with total BMD. There were 1747 participants in this study, 47.1% were female, 29.4% were white, 19.5% were black, and 22.3% were Mexican–American. And further subgroup analysis was conducted. The correlation between HS-CRP and total BMD was evaluated by using weighted multivariate linear regression models. population from the data of the National Health and Nutrition Examination Survey (NHANES). A cross-sectional study was performed in the normal U.S. The aim of this population-based study was to investigate the relationship between HS-CRP and total BMD in adolescents aged 10–20 years. There was very limited evidence linking high-sensitivity C-reactive protein (HS-CRP) and total bone mineral density (BMD) in adolescents. ![]()
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